Aberrant Regulation of RNA Methylation in Spermatogenesis m6A

Name: Aberrant Regulation of RNA Methylation in Spermatogenesis
Creator: Dandan Zhong
Keywords: health,sante

Updated on September 1, 2021 — License Not Specified

This dataset has been published on the initiative and under the responsibility of Dandan Zhong
Published on August 18, 2020 and updated on September 1, 2021

Dandan Zhong

1 datasets

health
sante

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License: License Not Specified
ID: 5f3bf4cf7f6887a3f00bce03

Temporality

Frequency: Unknown
Creation date: August 18, 2020
Latest resource update: August 18, 2020

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Territorial coverage granularity: Other

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Description

Figure 1-4 of the paper.

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m6A related proteins and functions.

Updated on August 18, 2020 — png (191.0Ko) — 1 downloads

The installation of m6A on mRNA is completed by m6A methyltransferase, mainly including METTL3, METTL14, METTL16, WTAP and ZC3H13; the reversal of m6A is achieved by the two demethylation transferases, FTO and ALKBH5; m6A works mainly through YTH domain proteins, of which YTHDC1 is related to the exportation and splicing of RNA, YTHDC2 is related to the stability of RNA, YTHDF2 is related to the degradation of RNA, YTHDF1 and YTHDF3 are related to the translation of RNA.

URL: https://download.data.public.lu/resources/aberrant-regulation-of-rna-methylation-in-spermatogenesis/20200818-174342/figure1.png
Permalink: https://data.public.lu/en/datasets/r/3cd7c24b-6ef8-4720-9a31-3bfef620e6dd
Type: Other
MIME Type: image/png
sha1: 6c2e994c85113543534c074f761b826bc8ddbc16
Created on: August 18, 2020
Modified on: August 18, 2020
Published on: August 18, 2020

m5C related proteins and functions.

Updated on August 18, 2020 — png (98.0Ko) — 0 downloads

The m5C modification is installed on mRNA by the methyltransferase which including NSUN family proteins and DNMT2. The RNA m5C modification may can be reversibly removed by TET family proteins. The biological functions of m5C modification are achieved by ALYREF, which affects RNA fate by regulating the RNA exportation.

URL: https://download.data.public.lu/resources/aberrant-regulation-of-rna-methylation-in-spermatogenesis/20200818-174721/figure2.png
Permalink: https://data.public.lu/en/datasets/r/517d6fbe-4be2-46a7-8a29-d714fca93a9f
Type: Other
MIME Type: image/png
sha1: b404db0ccecedad68f14009f13c71476a9575689
Created on: August 18, 2020
Modified on: August 18, 2020
Published on: August 18, 2020

The process of spermatogenesis

Updated on August 18, 2020 — png (194.4Ko) — 0 downloads

Spermatogenesis mainly includes three processes, mitosis of spermatogonial stem cells, meiosis of spermatocytes and maturation of spermatozoa, and finally a spermatocyte will form four spermatozoon. The primary spermatocytes in the meiosis prophase I will go through four phases, which are leptonema, zygonema, pachynema and diplonema.

URL: https://download.data.public.lu/resources/aberrant-regulation-of-rna-methylation-in-spermatogenesis/20200818-174811/figure3.png
Permalink: https://data.public.lu/en/datasets/r/ebe9d664-edd5-4f75-b401-61060aad1d2d
Type: Other
MIME Type: image/png
sha1: 0ec9b344ea9ad225fd85f8ad48aff21451a52265
Created on: August 18, 2020
Modified on: August 18, 2020
Published on: August 18, 2020

The questions of RNA modification in spermatogenesis

Updated on August 18, 2020 — png (56.5Ko) — 0 downloads

RNA modification is an indispensable component in the process of spermatogenesis, including the period of mitosis, meiosis and sperm maturation. However, there are still many functions of m6A effectors in spermatogenesis that have not yet been discovered. “?” indicates unresolved questions.

URL: https://download.data.public.lu/resources/aberrant-regulation-of-rna-methylation-in-spermatogenesis/20200818-174858/figure4.png
Permalink: https://data.public.lu/en/datasets/r/33f28757-4d4a-4229-9588-7e65a1930088
Type: Other
MIME Type: image/png
sha1: c075b478c5acc068525ea598b9e61b909abb8349
Created on: August 18, 2020
Modified on: August 18, 2020
Published on: August 18, 2020

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